Table 1.
Clinical characteristics of 42 patients with large to giant pituitary adenomas in Knosp grade 4.
| Clinical characteristics | Value |
|---|---|
| Sex, male/female | 18/24 |
| Age (median ± SD [range]) (years) | 44 ± 13 (19–73) |
| Presenting symptoms, n (%) | |
| Impaired visual acuity | 35 (83.3) |
| Headache | 15 (35.7) |
| Endocrinopathy | 10 (23.8) |
| Incidental | 1 (2.4) |
| Recurrence | 6 (14.3) |
| Vision, n (%) | |
| Hemianopsia | 31 (73.8) |
| Cranial nerve deficit | 3 (7.1) |
| Other | 5 (11.9) |
| Normal | 4 (9.5) |
| Endocrinological types, n (%) | |
| Non-functioning adenomas | 36 (85.7) |
| Functioning adenomas | 6 (14.3) |
| PRL | 2 (4.8) |
| GH | 3 (7.1) |
| ACTH | 1 (2.4) |
| Endocrine function, n (%) | |
| Hypogonadism, male | 8 (44.4 a ) |
| Hypogonadism, female | 9 (37.5 b ) |
| Hypothyroidism | 5 (11.9) |
| Hypocortisolism | 5 (11.9) |
| Panhypopituitarism | 3 (7.1) |
a
Number of hypogonadism in male/total number of male patients.
b
Number of hypogonadism in female/total number of female patients.