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. 2022 May 12;12:807718. doi: 10.3389/fonc.2022.807718

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Copyright © 2022 Zhang, Sang, Peng, Li, Ou, Feng, Zou, Yuan and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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S. officinalis suppresses the pathways related to cell proliferation and migration. (A) The expression of PI3K, p-PI3K, Akt, p-Akt, HIF-1A, and VEGFA proteins in RKO and HCT-15 cells after S. officinalis treatment for 24 h. (B) The histogram shows the protein expression level normalized with GAPDH in the treatment and control groups. The results are expressed as mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001, compared with the control group. (C) Expression of MAPK (p44 and p42) and p-MAPK proteins. (D) The histogram shows the protein expression normalized with GAPDH in the treatment and control groups. The results are expressed as mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001, compared with the control group.