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. 2022 May 11;3(5):100614. doi: 10.1016/j.xcrm.2022.100614

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Cynomolgus macaque Bw6-specific CAR T cells are not pro-inflammatory

(A) Persistence of on-target Bw6⁺ aAPCs and off-target Bw6⁻ aAPCs after 24 h co-culture with Bw6-specific CAR Tregs or Bw6-specific CAR Teffs. aAPCs were transduced with mCherry to distinguish from CAR Teffs or CAR Tregs.

(B) Absolute number of aAPCs remaining in (A) were normalized to the number of cells in well with aAPCs alone (n = 2 independent experiments). Data are represented as mean ± SEM. (C and D) IL-2 secretion following 5 h co-culture between indicated cell types (n = 4) is shown. Data are represented as mean ± SEM, with each data point representing one independent experiment.