Table 1.

Patient characteristics and univariate analysis

		Radiation pneumonitis		Univariate analysis
Characteristic	All cases (n = 38)	Grade 0-1(n = 29)	Grade 2+(n = 9)	OR (95% CI)	P value
Age, mean (range), y	72 (30-88)	72 (30-86)	73 (56-88)	1.01 (0.94-1.10)	.86
Sex
Male	24	20	4	0.36 (0.07-1.66)	.19
Female	14	9	5
ECOG-PS
1+	18	12	6	2.83 (0.62-15.6)	.19
0	20	17	3
Smoking history*
Yes	25	19	6	1.26 (0.23-9.89)	.80
No	10	8	2
Interstitial pneumonia
Yes	3	3	0	NA	NA
No	35	26	9
Prior history of lung surgery
Yes	17	15	2	0.27 (0.04-1.33)	.14
No	21	14	7
Prior use of systemic therapy
Yes	14	10	4	1.52 (0.31-7.07)	.59
No	24	19	5
Prior use of radiation therapy
Yes	2	2	0	NA	NA
No	36	27	9
FEV1,† mean (range), L	1.80 (0.93-4.29)	1.87 (0.99-4.29)	1.49 (0.93-2.33)	0.38 (0.04-1.77)	.31
Lesions, n
Three	2	2	0	NA	NA
Two	36	27	9
Laterality
Ipsilateral	24	17	7	2.47 (0.49-18.6)	.31
Bilateral	14	12	2
Existence of lower lobe lesion
No	15	13	2	2.84 (0.57-21.3)	.24
Yes	23	16	7
Indication for SBRT
SPLC	17	12	5	1.77 (0.39-8.52)	.46
Oligometastatic disease	21	17	4

Abbreviations: CI = confidence interval; ECOG-PS = European Cooperative Oncology Group performance status; FEV₁ = forced expiratory volume in 1 second; NA = not applicable; OR = odds ratio; SBRT = stereotactic body radiation therapy; SPLC = synchronous primary lung cancer.

^⁎Data on smoking status were unavailable for 3 patients.

^†Data on FEV₁ were unavailable for 11 patients.