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. 2022 May 12;9:901565. doi: 10.3389/fmolb.2022.901565

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Copyright © 2022 Cui, Yang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTMs of GPX4. (A) Present identified PTMs sites of GPX4 from proteomics and drug research. mGPX4: mitochondrial isoform; cGPX4: cytosolic isoform. (B) Various PTMs have been found to modify GPX4 protein and regulate its protein level/activity in physiological and/or pathophysiological conditions. HLRCC: hereditary leiomyomatosis and renal cell cancer; NSCLS: non-small cell lung cancer; TNBC: triple-negative breast cancer cell; HRCEC: human retinal capillary endothelial cell; FINs: ferroptosis inducers.