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. 2022 May 3;3(5):100623. doi: 10.1016/j.xcrm.2022.100623

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Transcriptional profiling and pattern of dissemination of patient-derived xenografts of BMs

(A and B) RNA sequencing of human BMs (n = 9) from diverse primary tumors and their matched PDXs (n = 11) reveals similar gene expression profiles in the (A) heatmap analysis and in the (B) PCA plot.

(C) Overview of the study design and main findings. Scheme illustrating our cohort of BMs samples from cancer patients with diverse primary tumor origins, and their respective subcutaneous and intracardiac PDXs. This scheme depicts take rates, survival, and dissemination pattern in each established model.