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. 2022 May 17;3(5):100635. doi: 10.1016/j.xcrm.2022.100635

Figure 6.

Figure 6

Binding of bovine bNAbs to CD4bs

Highlighted on the BG505 SOSIP.664 trimer (top left) are residues from the D loop (275–283: SNFTDNAKN, pale pink), CD4 binding loop (362–375: NQSSGGDPEIVMHS, cyan), and V5 loop (458–469: GGNNHNNDTETFR, pale orange). Binding site of antibodies MEL-1842, MEL-1872, MEL-2129, and VRC01 to AD8 SOSIP V4.1 are shown with red color, indicating the residues that binding of bovine antibodies to them was reduced through mutagenesis. Homology model of AD8 SOSIP was obtained using Swiss Modeller.