Table 1.
Characteristics of patients with initial CNS disease (n = 13) and all peripheral T-cell lymphomas (n = 1,040).
| Characteristics | Initial CNS disease (n = 13 pts) | PTCL without initial CNS involvement (n = 1,027 pts) |
|---|---|---|
| Subtype of PTCL | ||
| PTCL-NOS | 10* | 406 |
| ALCL ALK neg. | 1 | 157 |
| ALCL ALK pos. | 0 | 74 |
| AITL | 1 | 108 |
| EATL | 1 | 38 |
| MEITL | 0 | 1 |
| Other | 0 | 243 |
| Age, median (range) years | 61.0 (24–80) | 60.0 (18–92) |
| Gender, Male/Female | 7/6 | 600/427 |
| Clinical stage | ||
| I(E) | 2* | 165 |
| II(E) | 0 | 183 |
| III(E) | 0 | 246 |
| IV | 11 | 433 |
| ECOG PS | ||
| 0 | 3 | 329 |
| 1 | 3 | 381 |
| 2 | 3 | 200 |
| 3 | 2 | 90 |
| 4 | 2 | 27 |
| B symptoms, Yes/No | ||
| 7/6 | 507/520 | |
| Bulky mass ≥10 cm, Yes/No | 2/11 | 107/920 |
| Number of extranodal sites | ||
| 0–1 | 3 | 819 |
| ≥2 | 10 | 208 |
| LDH ≥ ULN, Yes/No | 6/7 | 627/400 |
| International Prognostic Index | ||
| 0 | 0 | 228 |
| 1 | 2 | 106 |
| 2 | 1 | 219 |
| 3 | 4 | 246 |
| 4 | 4 | 121 |
| 5 | 2 | 107 |
| Involved CNS sites | ||
| Parenchymal | 6* | |
| Leptomeningeal | 4 | – |
| Parenchymal and leptomeningeal | 2 | – |
| Ocular and leptomeningeal | 1 | – |
| Deep brain structures involved | ||
| Yes/No | 3/10 | – |
| Cerebrospinal fluid protein concentration elevated | ||
| Yes/No/Missing | 6/3/4 | – |
pts, patients; PTCL, peripheral T-cell lymphoma; NOS, not otherwise specified; ALCL, anaplastic large cell lymphoma; ALK, anaplastic lymphoma kinase; AITL, angioimmunoblastic T-cell lymphoma; EATL, enteropathy-associated T-cell lymphoma; MEITL, monomorphic epitheliotropic intestinal T-cell lymphoma; ECOG PS, the Eastern Cooperative Oncology Group Performance status; LDH, lactate dehydrogenase; ULN, upper limit of normal. *Two patients with primary T CNS lymphoma.