Table 9.
Estimated coefficients, number of selected variables and AUCs for usual SSVS and SSVS using the power prior for the second approach with P0 = 2P, a0 ∈ {0.1, 0.5, 1}, BMA and several values of n0.
| Variables / Models | * | SSVS | Power prior (P0 = 2P) |
|||||
|---|---|---|---|---|---|---|---|---|
| a0 = 0.1 | a0 = 0.5 |
n0 = n0 a0 = 1 |
a0 = 0.1 | a0 = 0.5 |
n0 = 1.77 × n1 a0 = 1 |
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|
| ||||||||
| Intercept | – | −10.62 (1.36) | −4.66 (0.37) | −5.36 (0.7) | −11.15 (2.29) | −4.5 (0.39) | −5.28 (0.72) | −11.43 (1.84) |
| Age ≥80 years | 5/32 | 1.630.1 (0.68) | 1.330.1 (0.52) | 3.570.6 (1.95) | 8.821 (2.64) | 1.460.2 (0.81) | 3.770.7 (2.01) | 9.851 (2.74) |
| Weight loss > 10% | 0/5 | 1.69 (0.64) | 1.1 (0.41) | 1.690.3 (0.88) | 3.870.6 (2.83) | 1.04 (0.28) | 1.680.3 (0.66) | 3.780.6 (2.11) |
| ECOG performance status 1 | 47/381 | 0.6 (0.23) | 0.52 (0.19) | 0.54 (0.2) | 0.68 (0.2) | 0.5 (0.17) | 0.54 (0.21) | 0.75 (0.45) |
| ECOG performance status 2 | 25/100 | 1.870.1 (0.48) | 1.230.1 (0.43) | 1.230.1 (0.89) | 2.990.4 (3.04) | 1.22 (0.4) | 1,320.2 (0.89) | 3.290.4 (3.11) |
| ECOG performance status 3 | 2/11 | 1.61 (0.38) | 1.01 (0.23) | 2.580.5 (1.12) | 7.711 (1.5) | 0.99 (0.22) | 2.840.5 (1.65) | 8.71 (2.02) |
| ECOG performance status 4 | 3/21 | 1.24 (0.49) | 0.96 (0.2) | 2.240.6 (0.87) | 6.530.9 (2.25) | 0.95 (0.26) | 2.210.3 (0.96) | 7.131 (1.49) |
| Bilirubin >35 μmol/L | l/l | 5.941 (0.38) | 6.291 (0.79) | 6.961 (2.43) | 10.221 (1.07) | 6.291 (1.05) | 8.661 (2.11) | 13.461 (1.79) |
| Bilirubin >50 μmol/L | 2/5 | 4.390.7 (1.64) | 2.140.3 (0.99) | 3.610.6 (2.33) | 8.641 (2.89) | 2.020.4 (0.97) | 3.810.7 (2.08) | 9.551 (3.13) |
| Treatment line 3 | 8/46 | 1.28 (0.35) | 0.56 (0.2) | 0.49 (0.21) | 0.6 (0.18) | 0.53 (0.22) | 0.44 (0.21) | 0.55 (0.21) |
| Treatment line >3 | 6/43 | 1.76 (0.6) | 0.74 (0.2) | 1.01 (0.53) | 3.320.4 (3.09) | 0.69 (0.16) | 0.92 (0.46) | 3.010.4 (2.7) |
| Vomiting 1 | 11/54 | 1.330.1 (0.52) | 0.63 (0.16) | 0.67 (0.26) | 0.99 (0.32) | 0.61 (0.15) | 0.7 (0.29) | 1.090.1 (0.47) |
| Vomiting 2 | 5/13 | 2.210.4 (0.95) | 1.09 (0.49) | 1.770.4 (1.32) | 3.240.4 (2.9) | 0.9 (0.31) | 1.040.1 (1.15) | 1.760.2 (2.12) |
| Vomiting 3 | 1/2 | 3.690.4 (1.86) | 1.920.1 (1.43) | 2.590.1 (2.11) | 5.70.8 (2.04) | 2.020.2 (1.8) | 2.230.2 (1.42) | 5.230.5 (2.46) |
| Nausea 1 | 28/226 | 0.62 (0.13) | 0.28 (0.06) | 0.27 (0.11) | 0.39 (0.11) | 0.27 (0.07) | 0.25 (0.12) | 0.39 (0.2) |
| Nausea 2 | 13/60 | 0.63 (0.12) | 0.43 (0.06) | 0.45 (0.18) | 0.79 (0.6) | 0.42 (0.07) | 0.36 (0.11) | 0.46 (0.16) |
| Nausea 3 | 2/6 | 2.210.2 (2.27) | 0.9 (0.43) | 1.13 (0.57) | 2.850.4 (2) | 0.930.1 (0.51) | 1.13 (0.76) | 2.310.4 (1.47) |
| Diarrhea 1 | 28/218 | 0.48 (0.11) | 0.3 (0.09) | 0.31 (0.11) | 0.43 (0.16) | 0.28 (0.09) | 0.27 (0.13) | 0.34 (0.13) |
| Diarrhea 2 | 18/49 | 6.541 (1.88) | 1.820.3 (0.55) | 2.120.4 (1.14) | 5.051 (1.74) | 1.760.2 (0.52) | 2.410.5 (1.02) | 6.261 (0.98) |
| Diarrhea 3 | 4/6 | 6.490.9 (2.48) | 4.180.9 (1.44) | 6.871 (2.66) | 13.311 (4.02) | 3.940.9 (1.64) | 6.881 (3.08) | 13.931 (4.92) |
| Asthenia 1 | 41/368 | 0.66 (0.17) | 0.42 (0.07) | 0.52 (0.13) | 0.9 (0.3) | 0.41 (0.08) | 0.53 (0.15) | 0.93 (0.4) |
| Asthenia 2 | 32/150 | 0.83 (0.18) | 0.67 (0.22) | 1.02 (0.56) | 2.740.4 (2.23) | 0.65 (0.2) | 0.94 (0.53) | 2.530.4 (2.19) |
| Asthenia 3 | 4/21 | 2.260.4 (0.8) | 1.02 (0.23) | 2.360.3 (1.17) | 7.291 (1.85) | 0.98 (0.28) | 2.480.4 (1.28) | 7.411 (1.21) |
| Neutropenia 1 | 12/111 | 0.65 (0.15) | 0.35 (0.08) | 0.34 (0.08) | 0.58 (0.19) | 0.33 (0.07) | 0.32 (0.08) | 0.54 (0.25) |
| Neutropenia 2 | 9/67 | 0.65 (0.05) | 0.43 (0.07) | 0.41 (0.1) | 0.56 (0.22) | 0.4 (0.06) | 0.33 (0.06) | 0.46 (0.1) |
| Neutropenia 3 | 4/9 | 3.730.4 (2.12) | 1.730.3 (1) | 1.960.3 (1.4) | 3.760.3 (3.19) | 1.620.3 (0.77) | 1.960.3 (1.18) | 4.040.6 (2.92) |
| Neutropenia 4 | 1/5 | 1.81 (0.48) | 1.03 (0.23) | 1.690.1 (1.06) | 4.80.7 (2.52) | 1.06 (0.21) | 1.810.2 (0.53) | 6.031 (1.86) |
| Thrombopenia 1 | 15/104 | 1.490.1 (0.61) | 0.43 (0.09) | 0.39 (0.1) | 0.78 (0.24) | 0.4 (0.09) | 0.37 (0.1) | 0.83 (0.31) |
| Thrombopenia 2 | 2/6 | 3.220.3 (1.35) | 1.220.1 (1.01) | 0.55 (0.15) | 0.62 (0.2) | 1.170.1 (0.95) | 0.54 (0.14) | 0.66 (0.28) |
| Thrombopenia 3 | 0/1 | 3.21 (0.52) | 1.46 (0.19) | 2.460.3 (1.26) | 6.220.7 (3.69) | 1.32 (0.18) | 2.210.5 (0.97) | 4.730.7 (2.6) |
| Thrombopenia 4 | 0/1 | 1.13 (0.11) | 0.92 (0.07) | 1.01 (0.26) | 1.4 (0.54) | 0.93 (0.06) | 0.97 (0.15) | 1.23 (0.3) |
| Anemia 1 | 26/257 | 0.42 (0.09) | 0.17 (0.03) | 0.17 (0.04) | 0.27 (0.09) | 0.16 (0.03) | 0.17 (0.03) | 0.3 (0.08) |
| Anemia 2 | 12/36 | 3.250.8 (1.09) | 1.1 (0.26) | 0.8 (0.25) | 0.99 (0.43) | 1.08 (0.21) | 0.77 (0.15) | 0.88 (0.27) |
| Number of selected variables | – | 5 | 2 | 6 | 13 | 2 | 7 | 13 |
| AUC | – | 0.69 (0.04) | 0.69 (0.03) | 0.68 (0.04) | 0.69 (0.05) | 0.69 (0.03) | 0.69 (0.05) | 0.69 (0.05) |
Note: s, 0 ≤ s ≤ 1 is the proportion of times a variable is selected by the model. The * column indicates the proportion of dose reductions linked to the variable.