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. 2022 May 12;14:859265. doi: 10.3389/fnagi.2022.859265

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Copyright © 2022 Lee, Zhao, Wong, Chrysostomou, Crowston and Bui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Recovery of retinal function in 3- and 12-month-old Thy1-YFPh mice. (A) Group averaged ERG waveforms in 3-month-old mice (teal traces, treated eyes; gray traces, control eyes) at luminous energies representing predominantly ganglion cell responses (–4.90 log cd.s.m^–2) and outer retinal function (2.07 log cd.s.m^–2) at 3 (n = 10), 7 (n = 11), 14 (n = 12), and 28 days (n = 11). (B) Group averaged ERG waveforms in 12-month-old mice (orange traces, treated eyes; gray traces, control eyes) at 3 (n = 9), 7 (n = 9), 14 (n = 8), and 28 days (n = 9). (C–E) ERG responses from IOP-treated eyes expressed relative to their contralateral control eyes for (C) photoreceptor amplitude, (D) bipolar cell amplitude, and (E) ganglion cell amplitude (pSTR) in 3-month-old (teal bars) and 12-month-old (orange bars) mice. Error bars, SEM; #, two-way ANOVA p < 0.05.