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. 2022 May 12;14:859265. doi: 10.3389/fnagi.2022.859265

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Copyright © 2022 Lee, Zhao, Wong, Chrysostomou, Crowston and Bui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age comparison of ON (left column) and OFF (right column) RGCs in 3- and 12-month-old eyes 7 days after IOP elevation. (A,B) Area under curve in 3-month-old (teal) and 12-month-old (orange) eyes for control (unfilled bars) and IOP-treated (filled bars) of (A) ON (solid bars) and (B) OFF (patterned bars) RGCs. (C,D) Convex hull volume. (E,F) Peak position. 3-month-old ON [control, n = 12 cells (4 animals); treated, n = 13 cells (4 animals)] and OFF [control, n = 12 cells (4 animals); treated, n = 11 cells (4 animals)] RGCs. 12-month-old ON [control, n = 14 cells (3 animals); treated, n = 12 cells (4 animals)] and OFF [control, n = 10 cells (4 animals); treated, n = 12 cells (4 animals)] RGCs. Error bars, SEM; #, mixed effects model p < 0.05.