Table 3A.
Variation of DSA, estimated glomerular filtration rate (eGFR), and daily proteinuria pre-, at-, and post-studied biopsies in relation to TG categories.
| iTG (n = 134) | cAMR (n = 72) | cAAMR (n = 76) | Overall (n = 282) | p –value | |
|---|---|---|---|---|---|
| DSA–MFI intensicy at and after Bx (median IQR) | |||||
| MFI_max at Bx (median IQR) | – | 5071 (380–23137) | 9758 (327–22438) | 8701 (327–23137) | 0.15 |
| MFI_max at 6 months post Bx (median IQR) | – | 5109 (528–25113) | 10688 (330–23320) | 9310 (330–25113) | 0.08 |
| MFI_max at 1 year post Bx (median IQR) | – | 5018 (343–23302) | 13012 (397–26436) | 9039 (343–26436) | 0.05 |
| Model A: The eGFR values before and after Bx (ml/min/1.73 m2 median IQR) | |||||
| eGFR 6 months before Bx | 28.2 (15.3–66.1) | 33.3 (10.5–88.6) | 41.5 (11.9–83.6)** | 35.9 (7.7–88.6) | 0.03 |
| eGFR at Bx | 24.7 (4.0–70.0) | 28.0 (5.4–77.8) | 29.8 (7.5–57.8) | 26.0 (4.0–77.8) | 0.26 |
| eGFR 6 months after Bx | 23.8 (6.2–69.0) | 23.0 (9.8–88.7) | 21.0 (9.8–68.0) | 22.4 (6.2–88.7) | 0.91 |
| eGFR 1 year after Bx | 26.4 (6.7–70.6) | 25.6 (7.6–86.1) | 26.0 (6.6–69.6) | 26.2 (4.0–139.0) | 0.96 |
| eGFR3 years after Bx | 25.0 (8.0–46.0) | 24.4 (5.0–67.0) | 17.8 (9.9–70.0) | 22.5 (5.0–70.0) | 0.99 |
| eGFR 5 years after Bx | 21.5 (6.0–57.0) | 16.0 (5.0–51.0) | 20.0 (10.0–70.9) | 20.0 (5.0–70.9) | 0.43 |
| Model A: The decline of eGFR at and after the studied Bx (ml/min/1.73 m2 median IQR) | |||||
| Δ eGFR 6 months before Bx | −3.1 (−19.8–13.5) | −5.1 (−57.3–6.0)* | −11.0 (−53.8–32.5)** | −6.5 (−57.3–32.5) | 0.02 |
| Δ eGFR Bx to 6 months after Bx | −2.9 (−32.2–19.9) | −1.4 (−17.4–10.9) | −5.2 (−32.0–27.3) | −3.4 (−32.2–27.3) | 0.58 |
| Δ eGFR Bx to 1 year after Bx | −4.3 (−32.2–15.6) | −5.8 (−18.7–17.7) | −4.8 (−28.4–21.4) | −5.0 (−32.2–21.4) | 0.92 |
| Δ eGFR Bx to 3 years after Bx | −6.4 (−23.5–12.1) | −9.8 (−22.4–15.0) | −9.0 (−48.1–30.7) | −8.7 (−48.1–30.7) | 0.45 |
| Δ eGFR Bx to 5 years after Bx | −6.3 (−52.3–16.0) | −9.5 (−43.0–31.6) | −5.7 (−27.2–30.2) | −6.3 (−52.3–31.6) | 0.60 |
| Model B: The eGFR values before and after Bx (ml/min/1.73 m2 median IQR) | |||||
| eGFR 6 months before Bx | 28.2 (15.3–66.1) | 33.3 (10.5–88.6) | 41.5(11.9–83.6)** | 35.9 (7.7–88.6) | 0.03 |
| eGFR at Bx | 24.7 (4.0–70.0) | 28.1 (5.4–77.8) | 29.8 (7.5–57.8) | 25.8 (4.0–77.8) | 0.16 |
| eGFR 6 months after Bx | 16.9 (5.0–69.0) | 17.5 (5.0–86.1) | 22.7 (4.0–139.0) | 16.2 (5.0–88.7) | 0.26 |
| eGFR 1 year after Bx | 13.8 (5.0–70.6) | 14.8 (5.0–76.3) | 19.8 (5.0–68.0) | 17.0 (4.0–139.0) | 0.05 |
| eGFR3 years after Bx | 5.8 (5.0–46.0) | 11.1 (5.0–67.0) | 8.3 (5.0–70.0) | 8.9 (5.0–70.0) | 0.10 |
| eGFR 5 years after Bx | 5.4 (5.0–57.0) | 7.1 (5.0–51.0) | 6.3 (5.0–70.9) | 6.5 (5.0–70.9) | 0.12 |
| Model B: The decline of eGFR at and after Bx (ml/min/1.73m2 median IQR) | |||||
| Δ eGFR 6 months before Bx | −3.1 (−19.8–13.5) | −5.1 (−57.3–6.0)* | −11.0 (−53.8–32.5)** | −6.5 (−57.3–32.5) | 0.02 |
| Δ eGFR Bx to 6 months after Bx | −3.0 (−32.2–19.9) | −2.7 (−17.4–10.9) | −4.9 (−32.0–27.3) | −3.9 (−32.2–27.3) | 0.85 |
| Δ eGFR Bx to 1 year after Bx | −5.5 (−34.0–15.6) | −6.1 (−23.9–17.7) | −5.0 (−28.4–21.4) | −5.6 (−34.0–21.4) | 0.61 |
| Δ eGFR Bx to 3 years after Bx | −12.0 (−70.0–11.7) | −11.9 (−37.6–15.0) | −15.0 (−50.2–29.3) | −12.1 (−70.0–29.3) | 0.48 |
| Δ eGFR Bx to 5 years after Bx | −12.1 (−65.0–16.0) | −11.4 (−43.0–41.4) | −19.7 (−50.2–30.2) | −13.0 (−65.0–41.4) | 0.49 |
| The proteinuria excretion before and after Bx (mg/day median IQR) | |||||
| PU 6 months before Bx | 896 (39–6758) | 709(40–5312) | 866 (67–12181) | 835 (39–12181) | 0.54 |
| PU at Bx | 1474 (54–6962) | 1271 (87–8366) | 955 (90–6540) | 1081(54–8366) | 0.30 |
| PU 6 months after Bx | 1040 (93–5807) | 1019(48–11597) | 1062 (65–9886) | 1040 (48–11597) | 0.73 |
| PU 1 year after Bx | 810 (82–5373) | 871 (82–5074) | 934 (66–6605) | 869 (82–6605) | 0.74 |
| PU 3 years after Bx | 645 (171–1681) | 998 (67–5204) | 667 (176–3186) | 725 (67–5204) | 0.32 |
| PU 5 years after Bx | 496 (94–7688) | 949 (94–2459) | 761 (73–4078) | 629 (73–7688) | 0.87 |
| The variation of proteinuria at and after Bx (mg/day median IQR) | |||||
| Δ PU 6 months before Bx | 163 (−3454–5744) | −42 (−4465–3187) | 116 (−3722–5050) | 121 (−4465–5744) | 0.09 |
| Δ PU Bx to 6 months after Bx | −125 (−5578–8732) | 44 (−950–8201) | 123 (−1920–6079) | −5 (−5578–8734) | 0.07 |
| Δ PU Bx to 1 year after Bx | −143 (−5781–3099) | 40 (−3619–1577) | 77 (−2184–7430) | −16 (−5781–7430) | 0.06 |
| Δ PU Bx to 3 years after Bx | 132 (−5308–2434) | 480 (−3000–3420) | 48 (−1713–3211) | 106 (−5308–3420) | 0.21 |
| Δ PU Bx to 5 years after Bx | 146 (−2606–2429) | 885 (−1566–1232) | 272 (−653–1891) | 147 (−2606–2429) | 0.85 |
The values were expressed as median and IQR.
MFI, mean fluorescent intensity; eGFR, estimated glomerular filtration rate; ΔeGFR, difference of eGFR value.
PU, daily urine protein excretion; ΔPU, difference of PU value.
Model A, the eGFR values after graft loss or death were not imputed.
Model B, the eGFR values after graft loss or death was imputed as 5 ml/min/1.73 m2.
**
p < 0.01, comparing with iTG;
*
p < 0.05, comparing with iTG.
The bold values indicates all p-values less than 0.05.