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Working model of the impact of ethanol on CD4+ T cell energy metabolism and mitochondrial dynamics. Our results show that ethanol increases CD4+ T cell glycolytic processes, decreases mitochondrial respiration, and dysregulates gene expression important for CD4+ T cell mitochondrial maintenance and mitophagy. Blue denotes gene expression affected by DIFF and green denote gene expression affected by EtOH. Cyan denotes gene expression affected by both DIFF and EtOH.
