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. 2022 May 12;10:852752. doi: 10.3389/fcell.2022.852752

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Copyright © 2022 Komada and Nishimura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Involvement of environmental and genetic factors in the epigenetic dysregulation and neuroinflammation associated with neurodevelopmental disorders. Perinatal environmental insults such as alcohol and cocaine exposure during development and/or genetic risks such as mutation of MECP2 and UHRF1 can cause epigenetic dysregulation in microglia, including the expression of microRNAs important for the development and function of microglia, leading to neuroinflammation and neurodevelopmental disorders. Zebrafish, as well as rodents, can be used to analyze the effect of such factors.