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. 2022 May 12;16:884296. doi: 10.3389/fncel.2022.884296

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Copyright © 2022 Wang, Wei, Yuan, Mao, Wang, Xing, Gu, Lin, Wang, Zhang and Xing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fat mass and obesity-related protein affects the maturation of brain-derived neurotrophic factor by regulating MMP-9. (A) The expression of MMP-9 mRNA 21 days after ACC injection of AAV in Sham and CCI mice. (B,C) The expression of MMP-9, proBDNF, and mBDNF proteins 21 days after ACC injection of AAV-FTO in the Sham group and CCI group (*P < 0.05, ***P < 0.001 vs. Sham-AAV-EGFP, ^##P < 0.01, ^###P < 0.001 vs. CCI-AAV-FTO). (D) The expression of MMP-9 mRNA 21 days after ACC injection of AAV in naïve mice. (E,F) Changes in protein levels of MMP-9, proBDNF, and mBDNF in naïve mice after ACC injection of AAV for 21 days (**P < 0.01 vs. AAV scrRNA).