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. 2022 May 26;27(9):3573–3582. doi: 10.1038/s41380-022-01623-6

Table 1.

Stages of differentiation of the human choroid plexus according to Netsky and Shuangshoti [136].

Stage 1 Stage 2 Stage 3 Stage 4
Time of development 7th Week 9th Week 17th week 29th week
Duration of development 2 Weeks 8 weeks 12 weeks 11 weeks
Epithelium Pseudo-stratified, tall, central nuclei Low columnar, apical nuclei Cuboidal, apical and central nuclei Cuboid or squamous, central and basal nuclei
Glycogen Absent Abundant Moderate Minimal and absent
Villi Absent Sparse Primary villi Villi with multiple fronds
Stroma Loose mesenchyme Small numbers of connective fibres Moderate numbers of fibres Large numbers of fibres and meningocytes
Blood Vessels Ill-defined vascular walls Defined vascular walls Well-formed vascular walls Same
Size in relation to ventricle Tiny Extremely large Moderately large Small