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. 2022 May 12;9:868833. doi: 10.3389/fnut.2022.868833

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Copyright © 2022 Jiang, Zhang, Yao, Huang, Wang, Huang, He and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In the hippocampus of CSDS mice, ginsenosides Rb1 reduced the NLRP3 inflammasome and microglial activation. Western blots analysis demonstrates (A) results of protein expression in the hippocampus of CSDS mice; (B) NLRP3; (C) ASC; (D) Cleaved Caspase-1; (G) IL-1β; (E) Immunohistochemical staining of Iba-1 in the hippocampus of CSDS mice (×400); (F) The number of Iba-1 positive cells. The entire data has been presented are means ± SEM; N = 4 mice per group. ^#p, and ^##p < 0.05, and 0.01, significantly different from control; ^*p and ^**p < 0.05, and 0.01, considerably varied from CSDS group.