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. 2022 May 12;13:903599. doi: 10.3389/fphar.2022.903599

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Copyright © 2022 Li, Zhu, Chen, Zhang, Zhang, Zhang, Wang, Jiang, Lin, Wu, Mo, Sze and Yung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IATL inhibits the proliferation of CRC cells. (A) Chemical structure of IATL. (B) HCT116 and SW620 cells were treated with various concentrations of IATL for 24 or 48 h. Cell viability was measured using MTT assays. (C) IATL inhibited the colony formation ability of HCT116 and SW620 cells. (D) Effect of IATL on the proliferation of HCT116 and SW620 cells was examined using the EdU staining assays. The nuclei were stained using Hoechst33342. The percentage of EdU-positive cells are presented in the right panels. Data are shown as mean ± SD of three independent experiments, **p < 0.01 vs. vehicle control.