Table 2.
Supratotal resection of WHO grade II gliomas (literature review).
| Number of patients | Tumor classification (WHO grading) | Definition of supratotal resection | Number of supratotal resection case (%) | Adjuvant therapy | Clinical outcome | Mean follow-up duration and outcomes | |
|---|---|---|---|---|---|---|---|
| Yordanova et al. (21) | 15 | WHO grade II glioma | Resection extending beyond the area of MRI signal abnormalities | 15 (100%) | None after the surgery (1 patient received radiotherapy at the relapse 6 years after the surgery) | Adjuvant treatment, anaplastic transformation, KPS, postop seizures, recurrence rate | 35.7 months Average time to recurrence: 38 months |
| Duffau et al. (67) | 11 | WHO grade II glioma | A margin of parenchyma was removed around the preoperative FLAIR-weighted signal abnormality with a larger volume of the surgical cavity as compared with the presurgical tumor volume | 3 (27.2%) | None after the surgery | Adjuvant treatment, KPS, postop seizures | 40.0 months No anaplastic transformation |
| Duffau et al. (20) | 16 | WHO grade II glioma | A complete removal of any signal abnormalities with a volume of the postoperative cavity larger than the preoperative tumor volume | 16 (100%) | None after the surgery, chemotherapy (n = 3), radiotherapy (n = 2) | Adjuvant treatment, KPS, malignant transformation, postop seizures, relapse time | 132 months Average time to relapse: 70.3 months |
| Lima et al. (69) | 21 | WHO grade II glioma | A margin of parenchyma was removed around the preoperative FLAIR or T2-weighted sequence signal abnormality, with a larger volume of the surgical cavity as compared with the presurgical tumor volume | 4 (19.0%) | Chemotherapy (n = 6), radiotherapy (n = 1) | Adjuvant treatment, KPS, postop seizures, tumor regrowth | 49 months Alive, enjoy a normal life |
| Lima et al. (68) | 19 | WHO grade II glioma | A margin of parenchyma was removed around the preoperative FLAIR or T2-weighted sequence signal abnormality, with a larger volume of the surgical cavity as compared with the presurgical tumor volume | 5 (26.3%) | Chemotherapy (n = 5), radiotherapy (n = 2) | Adjuvant treatment, KPS, postop seizures | 62.4 months PFS: not reached |
WHO, World Health Organization; KPS, Karnofsky Performance Status; NA, not available; MRI, magnetic resonance imaging; FLAIR, fluid-attenuated inversion recovery.