TABLE 2.
Baseline clinical and imaging characteristics of patients with small and non-small ICH.
| Small ICH (n = 94) |
Non-small ICH (n = 93) |
p-value | |
| Clinical characteristics | |||
| Age, mean (SD), year | 63.3 (14.3) | 61.5 (12.5) | 0.365 |
| Male, n (%) | 61 (63.5) | 66 (72.5) | 0.246 |
| Hypertension, n (%) | 85 (90.4) | 75 (80.6) | 0.090 |
| Diabetes, n (%) | 19 (20.2) | 23 (24.7) | 0.572 |
| Dyslipidemia, n (%) | 22 (23.4) | 25 (26.9) | 0.704 |
| Previous IS, n (%) | 4 (4.3) | 7 (7.5) | 0.372 |
| Previous ICH, n (%) | 6 (6.4) | 10 (10.8) | 0.420 |
| Current smoker, n (%) | 37 (39.4) | 33 (35.5) | 0.692 |
| Alcohol use, n (%) | 17 (18.1) | 24 (25.8) | 0.272 |
| Laboratory characteristics | |||
| Admission blood glucose, median (IQR), mmol/L | 7.8 (6.1–9.1) | 7.2 (6.0–8.6) | 0.465 |
| TC, mean (SD), mmol/L | 4.57 (0.99) | 4.48 (0.92) | 0.579 |
| TG, median (IQR), mmol/L | 1.12 (0.83–1.81) | 1.36 (0.80–1.65) | 0.672 |
| HDL-c, mean (SD), mmol/L | 1.28 (0.36) | 1.30 (0.38) | 0.758 |
| LDL-c, mean (SD), mmol/L | 2.85 (0.87) | 2.77 (0.82) | 0.519 |
| International normalized ratio, mean (SD) | 1.00 (0.08) | 1.00 (0.06) | 0.768 |
| Imaging characteristics | |||
| Lobar ICH, n (%) | 19 (20.2) | 38 (40.9) | 0.004 |
| Baseline hematoma volume, median (IQR), mL | 2.5 (0.9–5.6) | 19.0 (14.1–29.7) | <0.001 |
| Final hematoma volume, median (IQR), mL | 2.7 (0.9–6.3) | 20.6 (15.3–31.7) | <0.001 |
| Baseline intraventricular hemorrhage, n (%) | 10 (10.6) | 12 (12.9) | 0.800 |
| WMH Fazekas score, median (IQR) | 3 (2–5) | 2 (2–4) | 0.058 |
| Presence of lacune, n (%) | 43 (45.7) | 27 (29.0) | 0.027 |
| Severe CSO-PVS, n (%) | 21 (22.3) | 18 (19.4) | 0.747 |
| Severe BG-PVS, n (%) | 5 (5.3) | 6 (6.5) | 0.767 |
| Presence of CMB, n (%) | 78 (83.0) | 72 (77.4) | 0.441 |
| Strictly lobar CMB, n (%) | 9 (9.6) | 14 (15.1) | 0.359 |
| Non-strictly lobar CMB, n (%) | 69 (73.4) | 58 (62.4) | 0.144 |
| Total CMB count, median (IQR) | 5 (1–20) | 3 (1–8) | 0.010 |
| CMB ≥ 5, n (%) | 50 (53.2) | 33 (35.5) | 0.022 |
| Presence of cSS, n (%) | 5 (5.3) | 13 (14.0) | 0.079 |
| Global SVD score, median (IQR) | 3 (1–4) | 2 (1–3) | 0.014 |
BG, basal ganglia; CSO, centrum semiovale; cSS, cortical superficial siderosis; CMB, cerebral microbleed; ICH, intracerebral hemorrhage; IS, ischemic stroke; IQR, interquartile range; SD, standard deviation; SVD, small vessel disease; TC, total cholesterol; TG, triglyceride; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; PVS, perivascular space; WMH, white matter hyperintensity.