TABLE 4.

The multivariate linear regression analysis of associations between SVD markers and hematoma volume adjusted for age and male sex.

	Total cohort			Lobar ICH			Non-lobar ICH
	β	95% CI	p-value	β	95% CI	p-value	β	95% CI	p-value
Model 1: individual SVD markers*
Hypertension	−0.075	−0.339 to 0.188	0.573	−0.101	−0.479 to 0.276	0.592	−0.168	−0.311 to 0.159	0.358
Lobar ICH	0.482	0.268 to 0.696	<0.001	–	–	–	–	–	–
WMH Fazekas score	−0.014	−0.076 to 0.047	0.647	−0.025	−0.116 to 0.066	0.585	−0.007	−0.091 to −0.077	0.867
Presence of lacune	−0.173	−0.372 to 0.027	0.090	0.002	−0.370 to 0.375	0.990	−0.245	−0.487 to −0.004	0.046
CMB ≥ 5	−0.136	−0.347 to −0.074	0.203	−0.039	−0.404 to 0.325	0.829	−0.212	−0.473 to 0.049	0.110
Presence of cSS	0.289	−0.059 to −0.637	0.102	0.317	−0.049 to 0.683	0.088	0.127	−1.127 to 1.381	0.841
Model 2: global SVD score*
Hypertension	−0.089	−0.349 to 0.170	0.498	−0.098	−0.466 to 0.270	0.595	−0.187	−0.539 to 5.16	0.431
Lobar ICH	0.477	0.265 to 0.690	<0.001	–	–	–	–	–	–
Presence of cSS	0.274	−0.070 to 0.618	0.117	0.332	−0.017 to −0.680	0.062	−0.031	−1.270 to 1.209	0.961
Global SVD score	−0.084	−0.142 to −0.025	0.005	−0.029	−0.122 to 0.065	0.540	−0.112	−0.186 to −0.037	0.004

* Adjusted for age and male sex. Dependent variable was base-10 log-transformed hematoma volume. β, regression coefficient; CI, confidence interval; cSS, cortical superficial siderosis; CMB, cerebral microbleed; ICH, intracerebral hemorrhage; SVD, small vessel disease; WMH, white matter hyperintensity.