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. 2022 May 12;13:894534. doi: 10.3389/fimmu.2022.894534

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Copyright © 2022 Smith, Williams, Plunkett, Selvaraj, Lane, Zalduondo, Xue, Vogel, Channappanavar, Jonsson and Smith

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SARS-CoV-2-pneumococcal coinfection in K18-hACE2 mice. Kaplan-Meier survival curves (A), percent weight loss (B), cumulative clinical score (C), and temperature (D) of mice infected with SARS-CoV-2 (250 PFU; white circles, solid lines) followed by 10³ CFU D39 at 3 d (yellow diamonds, dotted lines), 5 d (magenta squares, dashed lines), or 7 d (cyan triangles, dash-dotted lines) pvi. Data are shown as the mean ± standard deviation (SD) and significant differences are indicated by *,P < 0.05; **,P < 0.01 for comparisons between SARS-CoV-2 infection and SARS-CoV-2-pneumococcal coinfection.