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. 2022 May 12;13:894534. doi: 10.3389/fimmu.2022.894534

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Copyright © 2022 Smith, Williams, Plunkett, Selvaraj, Lane, Zalduondo, Xue, Vogel, Channappanavar, Jonsson and Smith

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lung pathology during SARS-CoV-2 infection and pneumococcal coinfection. Average endothelial hypertrophy (A), peribronchiolar/perivascular lymphoid cells (B), interstitial inflammation/septal thickening (C), alveolar inflammation (D), extent of alveolar involvement (E), and consolidation (F) in lungs of mice infected with SARS-CoV-2 (250 PFU; open bars) followed by 10³ CFU D39 at 3 or 5 d pvi (filled bars). Plots represent the mean ± standard deviation (SD) bars for combined male and female groups.