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. 2022 May 12;13:880887. doi: 10.3389/fimmu.2022.880887

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Copyright © 2022 Bhattacharyya, Torre, Yadav, Boostanpour, Chen, Tsukui, Sheppard, Muramatsu, Seed, Nishimura, Jung, Tang, Allen and Bhattacharya

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MoMac Cx43 is required for lung fibrosis. (A) Schematic for testing the effect of macrophage-specific Cx43 deletion on lung collagen after bleomycin injury with Cx3cr1-CreERT2: Cx43 fl/fl mice and controls. (B) qPCR of Cx43 expression in sorted tdTomato+ macrophages from Cx3cr1-CreERT2: R26-LSL-tdtomato: Cx43 fl/fl mice and Cx3cr1-CreERT2: R26-LSL-tdtomato controls. N=3 mice per condition. P value is for unpaired one-tailed t-test (left). Hydroxyproline assay of whole lung collagen from Cx3cr1-CreERT2: Cx43 fl/fl mice and Cx3cr1-CreERT2 controls. N=4, 9, and 8 mice as shown. P value is for one-way ANOVA followed by Kruskal-Wallis multiple comparison test (right).