Table 1.
Description of CRC-derived cell lines
| Cell line | Tissue | Morphology | Disease | Biomarkers | MHC I molecule/cell | HLA genotyping | Mutations of interest |
|---|---|---|---|---|---|---|---|
| Colo205 | Colon; derived from metastatic site: ascites | Epithelial | Dukes' type D, colorectal adenocarcinoma | MSS, CIMP | 1.44 × 105 ± 0.00282 × 105 | HLA-A∗01:01 HLA-A∗02:01 | BRAF (V600E), SMAD4, TP53 |
| HLA-B∗07:02 HLA-B∗08:01 | |||||||
| HLA-C∗07:01 HLA-C∗07:02 | |||||||
| HCT116 | Colon | Epithelial | Colorectal carcinoma | MSI, CIMP | 5.07 × 105 ± 0.30 × 105 | HLA-A∗01:01 HLA-A∗02:01 | RAS (G13D), PI3CA, CDKN2A, CTNNB1 (B-catenin) |
| HLA-B∗18:01 HLA-B∗45:01 | |||||||
| HLA-C∗05:01 HLA-C∗07:01 | |||||||
| RKO | Colon | Epithelial | Carcinoma | MSI, CIMP | 2.82 × 105 ± 0.11 × 105 | HLA-A∗03:01 | BRAF (V600E), PI3CA |
| HLA-B∗18:01 | |||||||
| HLA-C∗07:01 | |||||||
| SW620 | Colon; derived from metastatic site: lymph node | Epithelial | Dukes' type C, colorectal adenocarcinoma | MSS, CIN | 1.69 × 105 ± 0.0017 × 105 | HLA-A∗02:01 HLA-A∗24:02 | APC, RAS (G12V), SMAD4, TP53 |
| HLA-B∗07:02 HLA-B∗15:18 | |||||||
| HLA-C∗07:02 HLA-C∗07:04 |