Table 3.

Biological relevance of TSA source genes in CRC

Source gene	Reference	Biological relevance in CRC
COL11A1—Collagen type XI alpha 1	PMID: 33597969	Upregulated in CRC (mRNA), marker of poor prognosis, role in CRC development
CYP39A1—cytochrome P450, family 39, subfamily A, polypeptide 1	PMID: 27341022	Expression is increased in CRC with poor prognosis
DPH6—Diphthamine biosynthesis 6		No known association
GRIN2B—Glutamate ionotropic receptor NMDA type subunit 2B	PMID: 27243824	Identified as nondriver hub gene involved in progression to stage II CRC
HKDC1—Hexokinase domain-containing protein 1	PMID: 30005951	HKDC1 contributes to increased metabolism, proliferation, and metastasis of CRC cells
HSPD1—Heat shock protein family D (Hsp60) member 1	PMID: 28261350; PMID: 29246022	Differentially expressed in CRC, potential biomarker for diagnosis; exosomal HSPD1 identified as putative diagnostic and prognostic biomarker in CRC
IPP (KLHL27)—Intracisternal A particle-promoted polypeptide	Human Protein Atlas (PMID: 28818916)	Favorable prognostic marker in colorectal cancer, unfavorable in renal and liver cancers
LY6G6F-LY6G6D readthrough—Lymphocyte antigen 6 family member G6F and G6D	PMID: 26894861	LY6G6D/F overexpressed in CRC, potential cell surface marker
NKD1—Naked cuticle homolog 1	PMID: 25446263; PMID: 19956716	Negative feedback regulator of Wnt pathway, intestinal tumor marker in mice; mutations in NKD1 alter Wnt signaling
PATJ—PALS1-associated tight junction protein		No known association
PLK1—Serine/threonine-protein kinase PLK1/polo-like kinase 1	PMID: 22648245	Overexpressed in CRC, associated with metastasis and invasion
SUCNR1—Succinate receptor 1	PMID: 32365557	SUCNR1 activation induces Wnt ligand expression and activates WNT signaling and EMT in a CRC-derived cell line
TRPC6—Transient receptor potential cation channel subfamily C member 6	PMID: 26422106	mRNA expression of TRPC6 lower in CRC than in normal tissue, may contribute to tumorigenesis