Table 2. Results of Numeric Optimization for SLNs of Abiraterone Acetatea.
| variable | goal | lower limit | upper limit |
|---|---|---|---|
| Critical Material Attributes | |||
| A: concentration of GMS (mg) | in range | 40 | 60 |
| B: concentration of Tween 80 (%) | in range | 3 | 5 |
| C: concentration of Poloxamer 407 (mg) | in range | 1 | 2 |
| Critical Quality Attributes | |||
| Y1: particle size (nm) | in range | 100 | 250 |
| Y2: polydispersity index | in range | 0.1 | 0.3 |
| Y3: Entrapment efficiency (%) | in range | 70% | 90% |
| predicted
solutions | ||||||
|---|---|---|---|---|---|---|
| A | B | C | PS | PDI | EE | desirability value |
| 44.9 | 4.5 | 1.8 | 209.3 | 0.28 | 70.1 | 1.00 |
| 42.8 | 3.8 | 1.8 | 204.4 | 0.31 | 70.5 | 1.00 |
| 46.0 | 4.6 | 1.8 | 223.5 | 0.28 | 70.3 | 1.00 |
a
PS, particle size; PDI, polydispersity index; EE, entrapment efficiency.