Table 3. Pharmacokinetic Parameters of Abiraterone Acetate Observed from SLNs and Free Drug Suspension in Wistar Rats.
| pharmacokinetic
parametersa |
||||||
|---|---|---|---|---|---|---|
| treatments typed | cmax (ng/ml)b | AUC0-t (ng/mL/h)b | Tmax (h)b | Ke (h–1)c | MRT (h)c | T0.5 (h–1)c |
| free drug | 44.11 ± 6.46 | 500.66 ± 8.76 | 6.56 ± 0.34 | 3.34 ± 1.01 | 7.33 ± 0.87 | 4.82 ± 1.72 |
| SLNs | 672.12 ± 7.21 | 4257.98 ± 10.29 | 3.35 ± 0.75 | 2.71 ± 0.98 | 6.88 ± 1.11 | 3.91 ± 0.98 |
a
Data expressed as mean ± SD (n = 6).
b
Highly significant difference (p < 0.001).
c
Significant difference (p < 0.05).
d
Significant statistical difference in parameters of SLNs vis-à-vis free drug suspension.