Table 2.
Risk of thrombocytopenia according to bacterial species
Univariable analysis | Multivariable analysesa | ||||
---|---|---|---|---|---|
Odds ratio | 95% Confidence interval | Odds ratio | 95% Confidence interval | P value | |
E. coli and S. pneumoniae bacteraemia | 1.0 | Ref. | 1.0 | Ref. | |
S. aureus bacteraemia | 1.1 | 0.7–1.7 | 1.2 | 0.7–1.9 | 0.58 |
Age, per 1 year increase | 1.0 | 1.0–1.0 | 1.0 | 1.0–1.0 | 0.66 |
Male sex | 1.5 | 1.0–2.1 | 1.9 | 1.2–2.9 | 0.01 |
Pulmonary disease | 0.6 | 0.3–1.0 | 0.5 | 0.3–1.0 | 0.05 |
Kidney disease | 1.7 | 1.0–2.9 | 2.0 | 1.0–3.8 | 0.04 |
Hypotensionb | 3.2 | 1.9–5.6 | 1.8 | 0.9–3.6 | 0.13 |
Hypoperfusionc | 1.9 | 1.3–2.9 | 1.4 | 0.8–2.2 | 0.23 |
Organ dysfunctiond | 2.1 | 1.40–3.0 | 1.6 | 1.0–2.5 | 0.08 |
ICU care | 3.7 | 2.1–6.7 | 2.0 | 0.9–4.4 | 0.11 |
Estimated by logistic regression in 462 subjects with complete information, adjusted for all other variables in the table.
Defined as systolic blood pressure <90 mmHg and/or treatment with vasopressors.
Defined as any lactate >3.2 mmol/l or base excess ⩽−5 (in patients without chronic kidney failure).
Defined as either kidney dysfunction (increase >45 µmol/l in S-creatinine in patients without chronic kidney dysfunction or CRRT or dialysis treatment), liver dysfunction (S-bilirubin >45 mmol/l in patients without chronic liver disease or diagnosis of acute pancreatitis, cholecystitis or cholangitis), hypoxemia (oxygen saturation <87% or <79% if pneumonia or mechanical ventilation); altered mental status; coagulation dysfunction (INR>1.5 or APTT>60 s in patients without warfarin or heparin treatment).