TABLE 3.
Pharmacokinetic values of 25–106 in the brain.
| Dose (mg/kg) | Ke (1/h) | T1/2 (h) | Cmax Ng/g | Clast Ng/ml | AUC24h h*mg/L | V L | CL L/h |
|---|---|---|---|---|---|---|---|
| 10 | 0.06 ± 0.06 | 17.20 ± 10.39 | 101.13 ± 23.65 | 2.27 ± 1.44 | 0.08 ± 0.02 | 77.39 ± 25.63 | 3.98 ± 2.18 |
| 50 | 0.11 ± 0.02 | 6.23 ± 1.12 | 118.25 ± 76.70 | 2.73 ± 1.75 | 0.09 ± 0.03 | 151.24 ± 58.36 | 16.57 ± 4.19 |
| 100 | 0.14 ± 0.02 | 5.03 ± 0.69 | 376.88 ± 289.08 | 2.88 ± 1.16 | 0.18 ± 0.07 | 126.99 ± 46.68 | 17.75 ± 6.77 |
| 200 | 0.17 ± 0.04 | 4.39 ± 1.19 | 668.75 ± 315.86 | 13.97 ± 14.54 | 0.96 ± 0.86 | 76.07 ± 73.66 | 11.29 ± 9.51 |
Values expressed represent group averages ± SD, single injection (n = 4 per group).