TABLE 4.
Pharmacokinetic values of 25–106 in the liver.
| Dose (mg/kg) | Ke (1/h) | T1/2 (h) | Cmax Ng/ml | Clast Ng/ml | AUC24h h*mg/L | V L | CLL/h |
|---|---|---|---|---|---|---|---|
| 10 | - | - | 1760 ± 526.43 | 85.18 ± 32.60 | 3.08 ± 1.01 | - | - |
| 50 | - | - | 512.75 ± 22.01 | 252.73 ± 200.06 | 2.76 ± 0.98 | - | - |
| 100 | - | - | 867.5 ± 378.22 | 150.9 ± 103.92 | 3.32 ± 1.28 | - | - |
| 200 | - | - | 2,807.5 ± 1,436.49 | 310.9 ± 247.48 | 5.44 ± 1.95 | - | - |
Values expressed represent group averages ±SD, single injection (n = 4 per group).
-Not measurable within the constraints of PK study as 25–106 was undetectable in samples at 24 h.