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. 2022 May 12;13:874878. doi: 10.3389/fimmu.2022.874878

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Copyright © 2022 Xia, Shi, Qian, Han, Lu, Tao, Gu, Zhao, Wei and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MgIG alleviated MTX-induced liver injury. (A) Experiment design. (B) Bodyweights during mouse model development (n = 8, Two-way ANOVA). (C) Liver index (liver weight/body weight) of each group (n = 8). (D, E) ALT and AST levels in serum(n = 8). (F) Representative H&E staining images of liver tissue from each group. Arrows and asterisks in the sections indicate histopathological differences between groups: inflammatory infiltration (arrow) and necrosis (asterisk). Scale bar, 100μm. (G) Histological score of liver tissue in each group (n = 6, Kruskal-Wallis test). ***p < 0.001, compared with Control group. ^#p < 0.05, ^#^#p < 0.01, ^###p < 0.001, compared with MTX group.