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Schematic illustration of the therapeutic effects of magnesium isoglycyrrhizinate (MgIG) on methotrexate (MTX)-induced intestinal and liver injuries: MTX induces intestinal barrier damage by altering the microbiota composition, which causes bacterial translocation and liver inflammation. However, MgIG treatment elevated Lactobacillus levels and restored the intestinal barrier, which acts as a protective barrier in MTX-induced liver injuries.
