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. 2022 May 12;13:874878. doi: 10.3389/fimmu.2022.874878

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Copyright © 2022 Xia, Shi, Qian, Han, Lu, Tao, Gu, Zhao, Wei and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MgIG alleviated MTX-induced intestinal injury. (A) Representative H&E staining of colon tissue sections from each group, Scale bar, 200μm. (B) Histological score in each group (n = 6, Kruskal-Wallis test). (C) Representative In vivo imaging of FITC-Dextran. (D) Intestinal leakage measured by FITC-Dextran concentration in serum (n = 6, One-way ANOVA). (E) Relative mRNA expression of tight junctions in liver tissue from each group (n = 3-5). (F) Immunoblot analysis of ZO-1, E-cadherin and Claudin-1 in colon tissues (n = 3). (G) Immunofluorescence analysis on ZO-1, E-cadherin and Claudin-1 in colon sections from different groups. Representative images are shown. Scale bar, 100μm. *p < 0.05, **p < 0.01, ***p < 0.001, compared with Control group. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, compared with MTX group.