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. 2022 May 12;13:874878. doi: 10.3389/fimmu.2022.874878

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Copyright © 2022 Xia, Shi, Qian, Han, Lu, Tao, Gu, Zhao, Wei and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MTX-induced intestinal barrier disruption was detected in advance of hepatic lesion (A) Experiment design. (B) Histological score of colon tissue (n = 6, Kruskal-Wallis test). (C) Representative in vivo imaging of FITC-Dextran leakage. (D) Quantification of intestinal leakage measured by FITC-Dextran concentration in serum (n = 5, One-way ANOVA). (E) Immunoblot analysis of ZO-1, E-cadherin and Claudin-1 in colon sections from different groups (n = 3, One-way ANOVA). (F) Quantification of Figure 3E. (G) Histological score of liver tissue (n = 6, Kruskal-Wallis test). (H, I) ALT and AST levels in serum (n = 6, One-way ANOVA). *p < 0.05, **p < 0.01, ***p < 0.001, compared with D0 or Control.