Table 1. Tyrosinase Inhibitory Efficiency of Synthesized Derivatives (2a–2p).
| compound No. | mushroom tyrosinase inhibitionaIC50 ± SEM (μM) |
|---|---|
| 2a | 5.68 ± 0.13 |
| 2b | 4.94 ± 0.16 |
| 2c | 3.90 ± 0.17 |
| 2d | 3.96 ± 0.14 |
| 2e | 3.46 ± 0.07 |
| 2f | 5.06 ± 1.00 |
| 2g | 4.40 ± 0.13 |
| 2h | 4.60 ± 0.15 |
| 2i | 1.55 ± 0.10 |
| 2j | 3.74 ± 0.28 |
| 2k | 1.70 ± 0.07 |
| 2l | 1.37 ± 0.01 |
| 2m | 1.16 ± 0.07 |
| 2n | 1.12 ± 0.04 |
| 2o | 1.45 ± 0.08 |
| 2p | 1.49 ± 0.8 |
| kojic acidb | 12.6 ± 0.6 |
a
IC50 values (mean ± standard error of the mean).
b
Standard inhibitor for mushroom tyrosinase.