Figure 1.

Bioactive micro- and nanomotors coated with antimicrobial peptides for the autonomous treatment of infections. Schematic of the AMP-coating process of the urease micro- and nanomotors and their autonomous propulsion to target pathogenic infections both in vitro and in vivo. Briefly, AMP–urease motors will encounter and hydrolyze urea (yellow spheres) in solution. The hydrolysis reaction will propel the motors, and when exposed to bacterial membranes, the AMPs onto their surface will act as antimicrobials and lyse bacterial cells in controlled (e.g., in vitro assays) and complex (e.g., infected wound) biological environments.