Fig. 1.

Overarching Pharmacology to payer system including ‘modules’. The solid lines indicate that adequate data exists to be able to create semi-mechanistic links to each of adjacent ‘modules’. The dotted lines and light grey describe where significant unknowns remain and are not mature enough to have been incorporated into the current framework. PopPK, population pharmacokinetic; SEIR, susceptible-exposed-infected-recovered; ß, the rate of infectivity; TShed, viral shedding; VK, viral kinetics.