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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Ophthalmology. 2022 Feb 8;129(6):694–707. doi: 10.1016/j.ophtha.2022.02.001

Figure 5: Association of AMD risk-raising variants with retinal layer thickness across known loci from Fritsche et al. Nature Genetics 2016.

Figure 5:

(a) Plot of 48 independent variants associated with AMD (from Fritsche et al. Nature Genetics 2016) and their respective associations with PS and RPE+BM thickness in SD. Labeled genes reflect the variants with P<1x10−4 for layer thickness. Curves and standard errors in panel (a) are from local polynomial regression fitting. (b) association of 48 individual AMD-risk-raising variants with 9 retinal layer thicknesses. ***: P≤5x10−8; **: 5x10−8<P≤1x10−4 ; *: 1x10−4<P<0.05. The black boxes reflect AMD risk variants genome-wide significantly associated with PS thinning and RPE+BM thickening. A table of all associations are all provided in Supplementary Table 9.