Table 1.

Main characteristics of the studies included in the meta-analysis

Author	Year	Country	Cancer	Sample	Method	patients number			OS		DFS		Follow up (months)	Data extraction method	NOS	Ref
						high expression	low expression	total	HR (95% CL)	P	HR (95% CL)	P
Li	2017	China	hepatocellular carcinoma	tissue	qRT-PCR	42	42	84	2.25(1.14–4.43)	0.019	NM	NM	25	reported	8	[8]
Chen	2018	China	osteosarcoma	tissue	qRT-PCR	66	66	132	1.90(1.15–3.13)	0.012	NM	NM	72	reported	8	[27]
Ding	2018	China	gastric cancer	tissue	qRT-PCR	38	34	72	1.19(0.47–3.03)	0.710	NM	NM	60	K-M	7	[11]
Li	2018	China	ovarian cancer	tissue	qRT-PCR	36	26	62	2.16(1.05–4.46)	0.036	NM	NM	60	K-M	7	[28]
Liu	2018	China	ccRCC	tissue	qRT-PCR	24	16	40	1.00(0.10–9.97)	0.999	1.20(0.21–6.81)	0.840	50	K-M	6	[15]
Peng	2018	China	gastric cancer	tissue	qRT-PCR	27	31	58	2.49(1.06–5.83)	0.036	NM	NM	60	K-M	7	[12]
Tuo	2018	China	bladder cancer	tissue	qRT-PCR	64	64	128	0.79(0.24–2.63)	0.706	0.83(0.37–1.84)	0.639	60	K-M	7	[16]
Wang	2018	china	ovarian cancer	tissue	qRT-PCR	30	30	60	NM	NM	NM	NM	NM	NM	6	[17]
Wang	2018	China	gastric cancer	tissue	qRT-PCR	30	34	64	1.82(1.09–3.04)	0.022	2.14(1.26–3.63)	0.005	70	K-M	7	[13]
Yang	2018	China	osteosarcoma	tissue	qRT-PCR	23	23	46	1.92(0.71–5.18)	0.199	NM	NM	50	K-M	6	[10]
Yao	2018	China	breast cancer	tissue	qRT-PCR	18	18	36	3.34(1.03–10.82)	0.045	NM	NM	50	reported	8	[18]
Yao	2018	China	cholangiocarcinoma	tissue	qRT-PCR	41	34	75	NM	NM	NM	NM	NM	NM	6	[29]
Zhang	2018	China	NSCLC	tissue	qRT-PCR	22	23	45	1.76(0.65–4.74)	0.267	NM	NM	60	K-M	6	[21]
Zhang	2018	China	brain glioma	tissue	qRT-PCR	24	23	47	2.46(1.13–5.35)	0.023	NM	NM	40	reported	8	[24]
Zhang	2018	China	gastric cancer	tissue	qRT-PCR	41	35	76	1.42(0.72–2.81)	0.310	NM	NM	60	K-M	6	[14]
Zou	2018	China	breast cancer	tissue	qRT-PCR	43	43	86	NM	NM	NM	NM	NM	NM	6	[19]
Cui	2019	China	pancreatic cancer	tissue	qRT-PCR	45	32	77	2.14(1.18–3.87)	0.012	NM	NM	50	K-M	7	[25]
Jia	2019	China	colorectal cancer	tissue	qRT-PCR	30	31	61	NM	NM	NM	NM	NM	NM	8	[26]
Liu	2019	China	lung adenocarcinoma	tissue	qRT-PCR	37	43	80	1.60(0.45–5.71)	0.467	NM	NM	60	K-M	6	[23]
Ma	2019	China	hepatocellular carcinoma	tissue	qRT-PCR	30	30	60	NM	NM	NM	NM	NM	NM	6	[9]
Zhang	2019	China	cervical cancer	tissue	qRT-PCR	NM	NM	56	2.37(0.75–7.50)	0.142	NM	NM	60	K-M	7	[20]
Zhu	2019	China	NSCLC	tissue	qRT-PCR	33	39	72	0.88(0.28–2.76)	0.825	NM	NM	60	K-M	8	[22]
Li	2019	China	colorectal cancer	tissue	qRT-PCR	33	37	70	1.31(0.59–2.92)	0.510	NM	NM	60	K-M	7	[32]
Liu	2020	China	gastric cancer	tissue	qRT-PCR	34	34	68	NM	NM	NM	NM	NM	NM	6	[30]
Liu	2020	China	breast cancer	tissue	qRT-PCR	25	20	45	NM	NM	NM	NM	NM	NM	6	[31]
Wang	2020	China	retinoblastoma	tissue	qRT-PCR	37	33	70	2.72(0.85–8.68)	0.090	NM	NM	60	K-M	7	[33]

Abbreviations: OS overall survival; DFS disease-free survival; HR hazard ratio; CI confidence interval; qRT-PCR quantitative reverse transcription polymerase chain reaction; NM not mentioned; K-M Kaplan–Meier plot; ccRCC Clear Cell Renal Cell Carcinoma; NSCLC non-small cell lung cancer; NOS Newcastle–Ottawa Scale, Ref reference