Table 4.
Summary of TP73-AS1 with their related signaling pathways
| Study | Cancer | Aberrant expression | Biological functions | Related signaling pathways |
|---|---|---|---|---|
| Li 2017 [8] | hepatocellular carcinoma | upregulation | promote cell proliferation | miR-200a/HMGB1/RAGE |
| Chen 2018 [27] | osteosarcoma | upregulation | promote cell proliferation, migration and invasion | |
| Ding 2018 [11] | gastric cancer | upregulation | promote cell growth and metastasis | miR-194-5p/SDAD1 |
| Li 2018 [28] | ovarian cancer | upregulation | promote cell proliferation | |
| Liu 2018 [15] | clear cell renal cell carcinoma | upregulation | promote cell proliferation, inhibit cell apoptosis | KISS/EZH2, PI3K/Akt/mTOR |
| Peng 2018 [12] | gastric cancer | upregulation | promote cell proliferation | HMGB1/RAGE |
| Tuo 2018 [16] | bladder cancer | downregulation | inhibit cell growth, cell cycle, migration and invasion, induce cell apoptosis | EMT |
| Wang 2018 [17] | ovarian cancer | upregulation | promoted cell proliferation, invasion, and migration | MMP2, MMP9 |
| Wang 2018 | gastric cancer | upregulation | promote cell proliferation, invasion | WNT/β-catenin |
| Yang 2018 [10] | osteosarcoma | upregulation | promote cell proliferation, invasion | miR-142/Rac1 |
| Yao 2018 [18] | breast cancer | upregulation | promote cell proliferation | miR-200a/TFAM |
| Yao 2018 [6] | cholangiocarcinoma | upregulation | promote cell proliferation, migration, invasion, inhibit cell apoptosis | |
| Zhang 2018 [21] | non-small cell lung cancer | upregulation | promote cell proliferation, tumor growth and cycle progression | miR-449a/EZH2 |
| Zhang 2018 [24] | brain glioma | upregulation | promote cell proliferation and invasion | miR-142/HMGB1/RAGE |
| Zhang 2018 [14] | gastric cancer | upregulation | promote cell migration and invasion | EMT/Bcl-2/caspase-3 |
| Zou 2018 [19] | breast cancer | upregulation | promote cell invasion and migration | miR-200a/ZEB1 |
| Cui 2019 [25] | pancreatic cancer | upregulation | promote migration and invasion | miR-141-3p/BDH2 |
| Jia 2019 [26] | colorectal cancer | downregulation | inhibite cell growth, promote apoptosis | miR-103/ PTEN |
| Liu 2019 [23] | Lung adenocarcinoma | upregulation | promote cell proliferation, migration, invasion, inhibit apoptosis | PI3K/AKT |
| Ma 2019 [9] | hepatocellular carcinoma | upregulation | promote cell proliferation, inhibit apoptosis | miR-103 |
| Zhang 2019 [20] | cervical cancer | upregulation | promote cell proliferation, migration and invasion | miR-607/cyclin D2 |
| Zhu 2019 [22] | non-small cell lung cancer | upregulation | promote cell proliferation. migration and invasion | miR-21 |
| Li 2019 [32] | colorectal cancer | upregulation | promote cell migration and invasion | TGF-β1 |
| Liu 2020 [30] | gastric cancer | downregulation | inhibit cell invasion and migration | miR-223-5p |
| Liu 2020 [31] | breast cancer | upregulation | promote cell proliferation, migration and invasion, inhibite apoptosis | miRNA-125a-3p/metadherin |
| Wang 2020 [33] | retinoblastoma | upregulation | promote cell proliferation, metastasis and invasion | miRNA-874-3p / TFAP2B |