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. Author manuscript; available in PMC: 2022 May 26.
Published in final edited form as: J Neuroendocrinol. 2020 May 14;32(6):e12856. doi: 10.1111/jne.12856

FIGURE 4.

FIGURE 4

Ghrelin stimulation of somato-dendritic vasopressin (VP) secretion. Ghrelin activation of growth hormone secretagogue receptors (GHSR) on vasopressin magnocellular neurosecretory cells (MNCs) induces somato-dendritic vasopressin secretion, which activates V1a receptors (V1aRs) on neighbouring astrocytes to increase intracellular calcium. Increased astrocytic calcium triggers release ofthe gliotransmitter, ATP, which activates ionotropic P2X receptors (P2XR) on GABA interneurones that project back to vasopressin MNCs