Table 2.
Grade evidence table for PICO 1.2.
| Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Hormone replacement therapy | Control | Relative (95% CI) | Absolute (95% CI) | ||
| Haemorrhagic stroke | ||||||||||||
| 5 | Randomised trials | Not serious | Not serious | Not serious | Seriousa | Publication bias strongly suspectedb | 45/21197 (0.2%) | 42/14222 (0.3%) | OR (0.49 to 1.15) | 1 fewer per (from 2 fewer to 0 fewer) | ⊕⊕○○ LOW |
CRITICAL |
| Haemorrhagic stroke – HRT | ||||||||||||
| 2 | Randomised trials | Not serious | Not serious | Not serious | Seriousa | Publication bias strongly suspectedb | 26/9886 (0.3%) | 25/9485 (0.3%) | OR 1.00 (0.57 to 1.74) | 0 fewer per 1,000 (from 1 fewer to 2 more) | ⊕⊕○○ LOW |
CRITICAL |
| Haemorrhagic stroke – Receptor modulator | ||||||||||||
| 3 | Randomised trials | Not serious | Not serious | Not serious | Not serious | Publication bias strongly suspectedb | 19/11311 (0.2%) | 17/4737 (0.4%) | OR 0.50 (0.26 to 0.97) | 2 fewer per 1,000 (from 3 fewer to 0 fewer) | ⊕⊕⊕○ MODERATE |
CRITICAL |
CI: Confidence interval; OR: Odds ratio; HRT. Hormone Replacement therapy.
aWide confidence intervals.
bFive or less studies reported this outcome.