Table 5.

Synoptic table of all recommendations.

Topic/PICO question	Recommendation	Expert consensus statement
1. Hormone replacement therapy (HRT) and stroke risk	In menopausal women we suggest against the use of HRT to reduce the risk of ischaemic stroke.
1.1. In menopausal women, does HRT compared to non-prior HRT reduce the risk of ischaemic stroke?	Quality of evidence: Very low ⊕
	Strength of recommendation: Weak against intervention ↓
1.2 In menopausal women, does HRT compared to non-prior HRT reduce the risk of haemorrhagic stroke in primary prevention?	In menopausal women we suggest against the use of HRT to reduce the risk of haemorrhagic stroke.
	Quality of evidence: Low ⊕⊕
	Strength of recommendation: Weak against intervention ↓
1.3 In menopausal women with acute ischaemic stroke, does prior HRT compared with non-prior HRT impact functional outcome and mortality?	In menopausal women with acute ischaemic stroke we suggest against the use of HRT to reduce mortality. Quality of evidence: Very low ⊕
	Strength of recommendation: Weak against intervention ↓
2. Treatment of acute ischaemic stroke in pre-menopausal women (pregnancy, postpartum, and menstruation)	Since only data from case reports are available, a specific recommendation on IVT in pregnant women cannot be made.	A majority of members suggests that pregnant women with acute disabling ischaemic stroke, can be treated with IVT.
2.1 In pregnant women with acute ischaemic stroke does intravenous thrombolysis (IVT) improve outcome as compared to no IVT?
2.2 In women with acute ischaemic stroke during the postpartum period does IVT improve outcome as compared to no IVT?	Since only data from case reports are available, a specific recommendation on IVT in postpartum women cannot be made.	All members suggest that postpartum women, occurring at least 10 days after delivery, can be treated with IVT.
2.3 In women with acute ischaemic stroke during menstruation does IVT improve outcome as compared to no IVT?	Since only data from case reports are available, a specific recommendation on IVT in women during menstruation cannot be made.	All members suggest that women with acute ischaemic stroke during menstruation, can be treated with IVT.
2.4 In women with acute ischaemic stroke during pregnancy does mechanical thrombectomy (MT) or intraarterial thrombolysis (IAT) improve outcome as compared to no MT and/or IVT?	Since only data from case reports are available, a specific recommendation on MT or IAT in pregnant women cannot be made.	All members suggest that pregnant women with stroke and large vessel occlusion can be treated with MT.
		A majority of members suggests that in pregnant women MT alone should be preferred over IVT or bridging therapy (IVT + ET).
2.5. In women with acute ischaemic stroke during postpartum period does endovascular treatment improve outcome as compared to no endovascular treatment and/or IVT?	No data, case reports available	It is reasonably plausible that postpartum women with stroke might benefit from MT.
		Furthermore, a majority of members suggests that is reasonably plausible to prefer MT alone over IVT or bridging therapy (IVT + ET)