Table 4.
Rates of treatment, case fatality, duration of stay, and case mix index.
| Control period | Study period | Odds ratio (95% CI) | p-Value | |
|---|---|---|---|---|
| Systemic thrombolysis | ||||
| Leading up to wave 1 | 14.3% (408) | 13.8% (414) | 0.97 (0.84–1.13) | 0.695 |
| Wave 1 | 14.3% (419) | 15.2% (383) | 1.06 (0.91–1.23) | 0.487 |
| Between waves 1 and 2 | 15.1% (686) | 15.4% (691) | 1.01 (0.90–1.14) | 0.802 |
| Wave 2 | 14.4% (907) | 15.1% (911) | 1.03 (0.93–1.14) | 0.548 |
| Wave 3 | 15.0% (690) | 14.5% (660) | 0.90 (0.79–1.01) | 0.068 |
| Wave 4 | 14.4% (725) | 14.1% (736) | 0.98 (0.87–1.09) | 0.690 |
| Mechanical thrombectomy | ||||
| Leading up to wave 1 | 5.8% (165) | 6.9% (206) | 1.24 (1.00–1.55) | 0.055 |
| Wave 1 | 6.7% (195) | 6.1% (153) | 0.89 (0.71–1.13) | 0.338 |
| Between waves 1 and 2 | 6.5% (298) | 7.4% (332) | 1.11 (0.94–1.32) | 0.222 |
| Wave 2 | 6.6% (416) | 6.9% (418) | 1.02 (0.87–1.18) | 0.838 |
| Wave 3 | 6.6% (302) | 5.8% (263) | 0.88 (0.73–1.05) | 0.155 |
| Wave 4 | 6.3% (210) | 6.1% (320) | 0.95 (0.80–1.12) | 0.552 |
| Decompressive craniectomy | ||||
| Leading up to wave 1 | 0.4% (11) | 0.4% (12) | 1.05 (0.46–2.39) | 0.906 |
| Wave 1 | 0.4% (11) | 0.4% (11) | 1.15 (0.49–2.66) | 0.751 |
| Between waves 1 and 2 | 0.5% (22) | 0.3% (14) | 0.65 (0.33–1.27) | 0.204 |
| Wave 2 | 0.4% (24) | 0.4% (25) | 1.06 (0.60–1.86) | 0.842 |
| Wave 3 | 0.4% (18) | 0.5% (23) | 1.37 (0.73–2.56) | 0.322 |
| Wave 4 | 0.5% (24) | 0.6% (32) | 1.38 (0.81–2.36) | 0.238 |
| Transfer to stroke unit among patients without mechanical ventilation | ||||
| Leading up to wave 1 | 59.8% (1,636) | 58.5% (1,681) | 0.99 (0.84–1.16) | 0.872 |
| Wave 1 | 60.9% (1,707) | 62.5% (1,507) | 1.17 (0.98–1.39) | 0.076 |
| Between waves 1 and 2 | 61.6% (2,670) | 63.7% (2,716) | 1.12 (0.98–1.28) | 0.103 |
| Wave 2 | 59.3% (3,552) | 63.9% (3,707) | 1.31 (1.31–1.31) | <0.001 |
| Wave 3 | 60.9% (2,670) | 63.9% (2,798) | 1.21 (1.06–1.38) | 0.006 |
| Wave 4 | 61.7% (2,963) | 61.5% (3,099) | 0.97 (0.86–1.09) | 0.578 |
| Mechanical ventilation | ||||
| Leading up to wave 1 | 4.3% (123) | 4.4% (131) | 1.02 (0.79–1.31) | 0.892 |
| Wave 1 | 4.3% (127) | 4.4% (112) | 1.01 (0.78–1.31) | 0.936 |
| Between waves 1 and 2 | 5.0% (227) | 4.7% (210) | 0.93 (0.77–1.14) | 0.498 |
| Wave 2 | 4.9% (312) | 4.2% (252) | 0.82 (0.69–0.98) | 0.027 |
| Wave 3 | 4.5% (208) | 4.2% (190) | 0.96 (0.78–1.18) | 0.701 |
| Wave 4 | 5.0% (252) | 3.7% (195) | 0.74 (0.61–0.90) | 0.003 |
| In-hospital case fatality | ||||
| Leading up to wave 1 | 6.2% (160) | 6.4% (175) | 1.05 (0.84–1.31) | 0.691 |
| Wave 1 | 6.0% (160) | 7.6% (177) | 1.27 (1.02–1.59) | 0.033 |
| Between waves 1 and 2 | 6.4% (264) | 5.4% (220) | 0.83 (0.69–1.00) | 0.045 |
| Wave 2 | 6.7% (383) | 7.1% (390) | 1.06 (0.92–1.23) | 0.418 |
| Wave 3 | 6.2% (258) | 6.0% (245) | 0.97 (0.81–1.16) | 0.710 |
| Wave 4 | 6.5% (294) | 5.4% (253) | 0.82 (0.69–0.98) | 0.025 |
| Duration of hospital stay (mean, days) | ||||
| Leading up to wave 1 | 9.2 ± 9.6 | 9.9 ± 9.7 | – | <0.01 |
| Wave 1 | 9.7 ± 9.6 | 8.3 ± 8.3 | – | <0.01 |
| Between waves 1 and 2 | 9.2 ± 8.9 | 8.7 ± 9.5 | – | <0.01 |
| Wave 2 | 9.7 ± 9.6 | 9.1 ± 10.9 | – | <0.01 |
| Wave 3 | 9.6 ± 9.1 | 8.8 ± 9.6 | – | <0.01 |
| Wave 4 | 9.3 ± 9.1 | 8.9 ± 8.4 | – | <0.01 |
| Case mix index (mean) | ||||
| Leading up to wave 1 | 1.68 ± 1.3 | 1.68 ± 1.2 | 0.66 | |
| Wave 1 | 1.71 ± 1.4 | 1.68 ± 1.6 | <0.01 | |
| Between waves 1 and 2 | 1.70 ± 1.2 | 1.70 ± 1.3 | 0.37 | |
| Wave 2 | 1.69 ± 1.3 | 1.62 ± 1.4 | <0.01 | |
| Wave 3 | 1.71 ± 1.3 | 1.55 ± 1.2 | <0.01 | |
| Wave 4 | 1.71 ± 1.2 | 1.54 ± 1.2 | <0.01 | |
CI: confidence interval.