Fig. 4.

Global analysis of SEV miRNAome and the effect of HIV infection comorbid with cocaine use. A Venn diagram showing common and unique miRNA among the clinical groups. B miRNA counts and distribution among the clinical groups. Error bars represent S.E.M. of 6 pools (n = 2) per group. Group comparison was achieved with an ordinary one-way Anova test (Tukey correction); ns, not significant. C Heatmap of the Jaccard coefficient depicting similarities and differences among clinical groups. D Pearson correlation showing differences in the enrichment level of the SEV miRNAome among the clinical groups. E Volcano plot showing up- (red) and down- (blue) regulated miRs in the Comorbid group as compared to the healthy group. F Heatmap of the union of KEGG pathways of the 16 Comorbid DP-miRs using mirPath v.3 with the default parameters