FIGURE 4.

The fraction of AlphaFold2 predictions with per‐residue local distance difference test (pLDDT) scores ≥70 increases as sequence conservation increases (a). Distributions of prediction confidences (quantified by pLDDT scores) are skewed lower for disordered proteins (red) than for single‐fold (gray) and fold‐switching proteins (blue). (b). Wider regions correspond to more populated prediction confidences. In both cases, conservation score was determined using Rate4Site; higher scores correspond to more conserved sequences. Gray/white backgrounds group protein regions with the same conservation score.