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. 2022 May 13;18(8):3484–3497. doi: 10.7150/ijbs.68995

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Fig 4 — CBX3 triggers the hyperactivation of TGF-β signaling pathway in pancreatic cancer. (A and B) GSEA indicated top 10 REACTOME signaling pathways induced by the overexpression of CBX3 in TCGA-PAAD dataset. Multi-GSEA plot showed running enrichment score for gene sets as the analyses walk down the preranked gene list (A). Ridge plot showed density of signaling pathway generated by using the frequency of fold change values per gene within each set (B). (C-F) REACTOME signaling by TGF-beta receptor complex was activated by the overexpression of CBX3 in TCGA-PAAD (C), ICGC-PACA-AU (D), ICGC-PACA-CA (E) and CPTAC-PDAC (F) datasets (all P < 0.05*).