Table 1.

Summary of the functions and mechanisms of miRNAs in peripheral nerve injury.

	Human orthologs	Injury model	Expression	Target	Function	Reference
miRNA-192-5p		Rat sciatic nerve crush	Upregulation	XIAP	Inhibition of miRNA-192-5p promote neurite outgrowth and decrease neurons apoptosis	50
miRNA-210		Mouse sciatic nerve crush		EFNA3	miRNA-210 overexpression promote axon regeneration and inhibit apoptosis	51
miRNA-26a	Human	Mouse sciatic nerve crush		GSK3β	Inhibition of miRNA-26a reduce axon regeneration	52
miRNA-9	Human	Mouse sciatic nerve crush		FoxP1	miRNA-9 overexpression inhibit axon regeneration	54
miRNA-1b	Human	Rat sciatic nerve transection	Downregulation	NDRG3	miRNA-1b overexpression inhibit proliferation, migration, and promote apoptosis of SCs	55
miRNA-1b	Human	Rat sciatic nerve transection	Upregulation	BDNF	miRNA-1b overexpression inhibit proliferation, migration, and promote apoptosis of SCs	56
miRNA let-7		Rat sciatic nerve crush		Ntn1	miRNA let-7 inhibit axon regeneration	58
miRNA-9	Human	Rat sciatic nerve crush		Dcc	miRNA-9 inhibit SCs migration and axon regeneration	58
miRNA-34a	Human	Rat sciatic nerve crush	Downregulation	CNTN2	miRNA-34a inhibit SCs proliferation and migration	60
miRNA sc-14		Rat sciatic nerve transection	Differential expression	FGFR2	miRNA sc-14 overexpression promote SCs proliferation and migration	62
miRNA-3099		Rat sciatic nerve crush	Upregulation	Aqp4/ St8sia2/ Tnfsf15 /Zbtb16	miRNA-3099 overexpression promote SCs proliferation and migration	63
miRNA-29a-3p	Human	Rat sciatic nerve crush	Upregulation	PMP22	miRNA-29a-3p overexpression inhibit SCs proliferation and migration	64
miRNA-485-5p	Human	Mouse sciatic nerve crush	Downregulation	Cdc42 and Rac1	miRNA-485-5p overexpression inhibit SCs proliferation and myelination	65
miRNA-221-3p	Human	Rat sciatic nerve resect		Nab1	miRNA-221-3p overexpression inhibit SCs myelination	66
miRNA-30c		Rat sciatic nerve transection	Differential expression		miRNA-30c promote SCs myelination	67