Table 2.
Summary of the functions and mechanisms of lncRNAs and circRNAs in peripheral nerve injury.
| Human orthologs | Injury model | Expression | Target | Function | Reference | |
|---|---|---|---|---|---|---|
| lncRNA BC089918/uc.217 | Rat sciatic nerve transection | Downregulation | Inhibition of lncRNA BC089918/uc.217 promote axon regeneration | 68,69 | ||
| lncRNA Silc1 | Human | Mouse sciatic nerve crush |
Upregulation | Sox11 | lncRNA Silc1 promote axon regeneration | 70 |
| lncRNA Arrl1 | Rat sciatic nerve crush | Downregulation | miRNA-761a/Cdkn2b | lncRNA Arrl1 inhibit neurite outgrowth | 72 | |
| lncRNA SNHG16 | Human | Rat sciatic nerve transection | Downregulation | miRNA-93-5p/STAT3 | lncRNA SNHG16 overexpression promote SCs proliferation and migration | 73 |
| lncRNA MALAT1 | Human | Mouse sciatic nerve crush |
Upregulation | miRNA-129-5p/BDNF | lncRNA MALAT1 overexpression promote SCs proliferation and migration | 74 |
| lncRNA Loc680254 | Rat sciatic nerve crush | Upregulation | Psrc1/Ska1 | lncRNA Loc680254 overexpression promote SCs proliferation | 75 | |
| lncRNA NEAT1 | Human | Mouse sciatic nerve crush |
Upregulation | miR-34a/Satb1 | lncRNA NEAT1 overexpression promote SCs proliferation, migration and axon regeneration |
76 |
| lncRNA BC088259 | Rat sciatic nerve crush | Upregulation | Vimentin | lncRNA BC088259 overexpression promote SCs migration | 77 | |
| lncRNA BC088327 | Rat sciatic nerve transection | Upregulation | Inhibition of lncRNA BC088327 suppress SCs proliferation and promote apoptosis | 78 | ||
| lncRNA MEG3 | Human | Rat sciatic nerve transection | Upregulation | PTEN/PI3K/AKT | Inhibition of lncRNA MEG3 promote SCs proliferation and migration | 79 |
| lncRNA TNXA-PS1 | Rat sciatic nerve crush | Downregulation | miRNA-24-3p/miRNA-152-3p/Dusp1 | Inhibition of lncRNA TNXA-PS1 promote SCs migration | 80 | |
| lncRNA MSTRG.24008.1 | Rat sciatic nerve crush | Upregulation | miRNA-331-3p/NLRP3/MAL | Inhibition of lncRNA MSTRG.24008.1 promote SCs proliferation | 81 | |
| circRNA-Spidr | Human | Rat sciatic nerve crush | Upregulation | PI3K-Akt | circRNA-Spidr promote axon regeneration | 83 |
| circRNA.2837 | Rat sciatic nerve crush | Downregulation | miR-34 | Inhibition of circRNA.2837 induce neurons autophagy | 84 | |
| circRNA-Ankib1 | Rat sciatic nerve crush | Downregulation | miR-423-5p/miR-485-5p/miR-666-3p/ Cyp26b1 | circRNA-Ankib1 inhibit SCs proliferation and axon regeneration | 85 |